Neurological complications as the hallmark symptoms of thrombotic thrombocytopenic purpura in sickle cell disease

Thrombotic thrombocytopenic purpura (TTP) is a type of microangiopathy, which characterized by the formation small blood clots in vessels, leading to organ damage and low platelet count. In sickle cell disease (SCD), TTP can occur due activation coagulation system endothelial cells lining vessels. The importance SCD lies its potential cause severe life-threatening complications, including stroke, renal heart failure. Early recognition treatment are crucial prevent these complications improve outcomes. this letter, we highlighted significance neurological diagnosis SCD.